Stem cells and breast cancer: A field in transit

被引：292

作者：

Smalley, M ^{[1
]}

Ashworth, A ^{[1
]}

机构：

[1] Inst Canc Res, Breakthrough Breast Canc Res Ctr, London SW3 6JB, England

来源：

NATURE REVIEWS CANCER | 2003年 / 3卷 / 11期

关键词：

D O I：

10.1038/nrc1212

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Evidence that supports the existence of a tumour stem cell for breast cancer has given fresh impetus to the search for an adult mammary epithelial stem cell in the normal breast. Such a cell might be responsible for routine tissue renewal and the massive expansion in epithelial tissue that the breast undergoes during pregnancy, and might be the cell of origin of most, if not all, breast tumours. So, what evidence is there that an adult mammary epithelial stem cell exists, what is its possible identity and what opportunities might the identification of such a cell present for the development of novel therapeutic and prophylactic strategies for treating breast cancer?

引用

页码：832 / 844

页数：13

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