Role of WUSCHEL in regulating stem cell fate in the Arabidopsis shoot meristem

被引：1446

作者：

Mayer, KFX ^{[1
]}

Schoof, H ^{[1
]}

Haecker, A ^{[1
]}

Lenhard, M ^{[1
]}

Jürgens, G ^{[1
]}

Laux, T ^{[1
]}

机构：

[1] Univ Tubingen, Lehrstuhl Entwicklungsgenet, D-72076 Tubingen, Germany

来源：

CELL | 1998年 / 95卷 / 06期

关键词：

D O I：

10.1016/S0092-8674(00)81703-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The shoot meristem gives rise to the aerial parts of higher plants by continuously initiating new organs. The basis of this activity is its ability to maintain a pool of pluripotent stem cells, which are the ultimate source of all tissues of the shoot. In Arabidopsis plants mutant for the WUSCHEL (WUS) gene, the stem cells are misspecified and appear to undergo differentiation. Here, we show that WUS encodes a novel homeodomain protein which presumably acts as a transcriptional regulator. The pattern of WUS expression suggests that stem cells in the shoot meristem are specified by an underlying cell group which is established in the 16-cell embryo and becomes localized to its prospective domain of function by asymmetric cell divisions.

引用

页码：805 / 815

页数：11

共 56 条

[1] BASIC LOCAL ALIGNMENT SEARCH TOOL [J].

ALTSCHUL, SF ;

GISH, W ;

MILLER, W ;

MYERS, EW ;

LIPMAN, DJ .

JOURNAL OF MOLECULAR BIOLOGY, 1990, 215 (03) :403-410

[2]

Barlow P., 1978, STEM CELLS TISSUE HO, P87

[3]

BARTON MK, 1993, DEVELOPMENT, V119, P823

[4] ONE OF 3 NUCLEAR-LOCALIZATION SIGNALS OF MAIZE ACTIVATOR (AC) TRANSPOSASE OVERLAPS THE DNA-BINDING DOMAIN [J].

BOEHM, U ;

HEINLEIN, M ;

BEHRENS, U ;

KUNZE, R .

PLANT JOURNAL, 1995, 7 (03) :441-451

[5]

BOWMAN J, 1994, ARABIDOPSIS ATLAS MI

[6] Arabidopsis intron mutations and pre-mRNA splicing [J].

Brown, JWS .

PLANT JOURNAL, 1996, 10 (05) :771-780

[7]

CLARK SE, 1993, DEVELOPMENT, V119, P397

[8]

Clark SE, 1996, DEVELOPMENT, V122, P1567

[9] Organ formation at the vegetative shoot meristem [J].

Clark, SE .

PLANT CELL, 1997, 9 (07) :1067-1076

[10] The CLAVATA1 gene encodes a putative receptor kinase that controls shoot and floral meristem size in Arabidopsis [J].

Clark, SE ;

Williams, RW ;

Meyerowitz, EM .

CELL, 1997, 89 (04) :575-585

← 1 2 3 4 5 6 →