Homocysteine and coronary atherosclerosis

被引：435

作者：

Mayer, EL

Jacobsen, DW

Robinson, K

机构：

[1] CLEVELAND CLIN FDN,DEPT CARDIOL,RES INST,CLEVELAND,OH 44195

[2] CLEVELAND CLIN FDN,DEPT CELL BIOL,RES INST,CLEVELAND,OH 44195

[3] CLEVELAND CLIN FDN,DEPT CLIN PATHOL,RES INST,CLEVELAND,OH 44195

[4] OHIO STATE UNIV,CLEVELAND,OH

来源：

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY | 1996年 / 27卷 / 03期

关键词：

D O I：

10.1016/0735-1097(95)00508-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Homocysteine is increasingly recognized as a risk factor for coronary artery disease. An understanding of its metabolism and of the importance of vitamins B-6 and B-12 and folate as well as enzyme levels in its regulation will aid the development of therapeutic strategies that, by lowering circulating concentrations, may also lower risk. Possible mechanisms by which elevated homocysteine levels lead to the development and progression of vascular disease include effects on platelets, clotting factors and endothelium. This review presents the clinical and basic scientific evidence supporting the risk and mechanisms of vascular disease associated with elevated homocysteine concentrations as well as the results of preliminary therapeutic trials.

引用

收藏

页码：517 / 527

页数：11

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