Evaluation of a Previously Suggested Plasma Biomarker Panel to Identify Alzheimer's Disease

被引：102

作者：

Bjorkqvist, Maria ^{[1
]}

Ohlsson, Mattias

Minthon, Lennart ^{[2
,3
]}

Hansson, Oskar ^{[3
]}

机构：

[1] Lund Univ, Brain Dis Biomarker Unit, Dept Expt Med Sci, Wallenberg Neurosci Ctr, Lund, Sweden

[2] Lund Univ, Clin Memory Res Unit, Dept Clin Sci Malmo, Malmo, Sweden

[3] Skane Univ Hosp, Neuropsychiat Clin, Malmo, Sweden

来源：

PLOS ONE | 2012年 / 7卷 / 01期

基金：

瑞典研究理事会;

关键词：

CEREBROSPINAL-FLUID; CSF BIOMARKERS; WORK GROUP; DIAGNOSIS; DEMENTIA; SIGNATURE;

D O I：

10.1371/journal.pone.0029868

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

There is an urgent need for biomarkers in plasma to identify Alzheimer's disease (AD). It has previously been shown that a signature of 18 plasma proteins can identify AD during pre-dementia and dementia stages (Ray et al, Nature Medicine, 2007). We quantified the same 18 proteins in plasma from 174 controls, 142 patients with AD, and 88 patients with other dementias. Only three of these proteins (EGF, PDG-BB and MIP-1 delta) differed significantly in plasma between controls and AD. The 18 proteins could classify patients with AD from controls with low diagnostic precision (area under the ROC curve was 63%). Moreover, they could not distinguish AD from other dementias. In conclusion, independent validation of results is important in explorative biomarker studies.

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