RANTES: a versatile and controversial chemokine

被引：628

作者：

Appay, V ^{[1
]}

Rowland-Jones, SL ^{[1
]}

机构：

[1] John Radcliffe Hosp, Inst Mol Med, Human Immunol Unit, Oxford OX3 9DS, England

来源：

TRENDS IN IMMUNOLOGY | 2001年 / 22卷 / 02期

关键词：

D O I：

10.1016/S1471-4906(00)01812-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

The activity of the chemokine RANTES is not restricted merely to chemotaxis. It is a powerful leukocyte activator, a feature potentially relevant in a range of inflammatory disorders. RANTES has attracted attention because it can potently suppress and, in some circumstances, enhance HIV replication. These characteristics are critically dependent on its ability to self-aggregate and bind to glycosaminoglycans.

引用

页码：83 / 87

页数：5

共 36 条

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