Crucial roles of Brn1 in distal tubule formation and function in mouse kidney

被引:108
作者
Nakai, S
Sugitani, Y
Sato, H
Ito, S
Miura, Y
Ogawa, M
Nishi, M
Jishage, K
Minowa, O
Noda, T
机构
[1] Japanese Fdn Canc Res, Dept Cell Biol, Inst Canc, Tokyo 1708455, Japan
[2] Tohoku Univ, Sch Med, Ctr Translat & Adv Anim Res Human Dis, Div Mol Genet, Sendai, Miyagi 9808575, Japan
[3] RIKEN, Genomic Sci Ctr, Mouse Funct Genomics Res Grp, Kanagawa 2440804, Japan
[4] RIKEN, Brain Sci Inst, Lab Cell Culture Dev, Wako, Saitama 3510198, Japan
[5] Miyagi Insurance Hosp, Sendai, Miyagi 9811103, Japan
[6] Tohoku Univ, Sch Med, Dept Nephrol Endocrinol & Vasc Med, Sendai, Miyagi 9808574, Japan
来源
DEVELOPMENT | 2003年 / 130卷 / 19期
关键词
Brn1; Henle's loop; kidney; distal tubule formation; POU transcription factor;
D O I
10.1242/dev.00666
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
This study identifies a role for the gene for the POU transcription factor Brn1 in distal tubule formation and function in the mammalian kidney. Normal development of Henle's loop (HL), the distal convoluted tubule and the macula densa was severely retarded in Brn1-deficient mice. In particular, elongation and differentiation of the developing HL was affected. In the adult kidney, Brn1 was detected only in the thick ascending limb (TAL) of HL. In addition, the expression of a number of TAL-specific genes was reduced in the Brn1(+/-) kidney, including Umod, Nkcc2/Slc12a1, Bsnd, Kcnj1 and Ptger3. These results suggest that Brn1 is essential for both the development and function of the nephron in the kidney.
引用
收藏
页码:4751 / 4759
页数:9
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