Tetrahydrobiopterin synthesis inhibitors induce nitric oxide synthesis in rat aorta

被引：4

作者：

Joly, GA

Kilbourn, RG

机构：

[1] Department of Genitourinary Oncology, University of Texas, M. D. Anderson Cancer Center, Houston, TX

[2] Department of Genitourinary Oncology, Box 13, University of Texas M. D. Anderson, Houston, TX 77030, Holcombe Boulevard

来源：

GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM | 1997年 / 28卷 / 03期

关键词：

D O I：

10.1016/S0306-3623(95)02012-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. Incubation of rate aortic rings with tetrahydrobiopterin synthesis inhibitors (NAS or DAHP) significantly decreased contractions to phenylephrine. These two compounds significantly potentiated the vascular hyporeactivity induced by endotoxin. Inhibitors of nitric oxide synthesis (NLA or MLA) restored the contractile responses to this alpha(1)-agonist in NAS- or DAHP-treated control rings and abolished the NAS- or DAHP-induced increased hyporeactivity to PE in endotoxin-treated aortic rings, These observations suggest that treatment of isolated blood vessels with BH4 synthesis inhibitors induces the production of NO. synthesis, resulting in turn in a vascular hyporeactivity to PE potentiated in endotoxin-treated preparations. Copyright (C) 1997 Elsevier Science Inc.

引用

页码：475 / 480

页数：6

共 28 条

[1] INTERLEUKIN-1 INDUCES PROLONGED L-ARGININE-DEPENDENT CYCLIC GUANOSINE-MONOPHOSPHATE AND NITRITE PRODUCTION IN RAT VASCULAR SMOOTH-MUSCLE CELLS [J].