Synthesis, analgesic and anti-inflammatory evaluation of some new 3H-quinazolin-4-one derivatives

被引：50

作者：

Alafeefy, Ahmed M. ^{[1
]}

Kadi, Adnan A. ^{[1
]}

El-Azab, Adel S. ^{[1
]}

Abdel-Hamide, Sami G. ^{[1
,2
]}

Daba, Mohamad-Hesham Y. ^{[2
]}

机构：

[1] King Saud Univ, Dept Pharmaceut Chem, Riyadh 11451, Saudi Arabia

[2] King Saud Univ, Coll Pharm, Dept Clin Pharm, Riyadh 11451, Saudi Arabia

来源：

ARCHIV DER PHARMAZIE | 2008年 / 341卷 / 06期

关键词：

analgesic; anti-inflammatory; COX-inhibitors; oxadiazole; 3H-quinazolin-4-one;

D O I：

10.1002/ardp.200700271

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In this study, we have synthesized a series of 3H-quinazolin-4-ones in order to obtain new compounds with potential analgesic and anti-inflammatory activity. The structures of the newly synthesized compounds were confirmed by means of infrared, nuclear magnetic resonance and mass spectroscopy. Some compounds were evaluated for their analgesic and anti-inflammatory activities by writhing and carrageenan-induced rat paw edema tests, respectively. In comparison to the standard drug indomethacine, compounds 4, 6c, 12-14, 16, 18, 19, and 22 induced significant reduction in the writhing response while compounds 6c, 12, 14, 16, 18, and 22 produced a good dose-dependent anti-inflammatory activity. The best dual analgesic / anti-inflammatory relative activity was observed with compounds 6c,14,16, 18, and 22.

引用

页码：377 / 385

页数：9

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