Chemical technologies for probing embryonic development

被引：22

作者：

Shestopalov, Ilya A. ^{[1
]}

Chen, James K. ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Dept Chem & Syst Biol, Stanford, CA 94305 USA

来源：

CHEMICAL SOCIETY REVIEWS | 2008年 / 37卷 / 07期

关键词：

D O I：

10.1039/b703023c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Embryogenesis is a remarkable program of cell proliferation, migration, and differentiation that transforms a single fertilized egg into a complex multicellular organism. Understanding this process at the molecular and systems levels will require an interdisciplinary approach, including the concepts and technologies of chemical biology. This tutorial review provides an overview of chemical tools that have been used in developmental biology research, focusing on methods that enable spatiotemporal control of gene function and the visualization of embryonic patterning. Limitations of current approaches and future challenges are also discussed.

引用

页码：1294 / 1307

页数：14

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