Characterization and differentiation of equine umbilical cord-derived matrix cells

被引：112

作者：

Hoynowski, Steven M.

Fry, Madeline M.

Gardner, Bryn M.

Leming, Matthew T.

Tucker, Jeanell R.

Black, Linda

Sand, Theodore

Mitchell, Kathy E.

机构：

[1] Vet Stem Inc, Poway, CA 92064 USA

[2] Univ Kansas, Dept Pharmacol & Toxicol, Lawrence, KS 66045 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2007年 / 362卷 / 02期

关键词：

Wharton's jelly; stem cells; mesenchymal cells; equine; adipogenic differentiation; osteogenic differentiation; chondrogenic differentiation; neuronal differentiation; Oct-4; umbilical cord matrix;

D O I：

10.1016/j.bbrc.2007.07.182

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Stem cells are being evaluated in numerous human clinical trials and are commercially used in veterinary medicine to treat horses and dogs. Stem cell differentiation, homing to disease sites, growth and cytokine factor modulation, and low antigenicity contribute to their therapeutic success. Bone marrow and adipose tissue are the two most common sources of adult-derived stem cells in animals. We report on the existence of an alternative source of primitive, multipotent stem cells from the equine umbilical cord cellular matrix (Wharton's jelly). Equine umbilical cord matrix (EUCM) cells can be cultured, cryogenically preserved, and differentiated into osteo-, adipo-, chondrogenic, and neuronal cell lineages. These results identify a source of stem cells that can be non-invasively collected at birth and stored for future use in that horse or used as donor cells for treating unrelated horses. (C) 2007 Elsevier Inc. All rights reserved.

引用

页码：347 / 353

页数：7

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