Biological performance of boron-modified bioactive glass particles implanted in rat tibia bone marrow

被引：90

作者：

Gorustovich, Alejandro A. ^{[1
]}

Lopez, Jose M. Porto

Guglielmotti, MAria B.

Cabrini, Romulo L.

机构：

[1] CNEA Reg Noroeste, Natl Atom Energy Comiss, Res Lab, RA-4408 Salta, Argentina

[2] Consejo Nacl Invest Cient & Tecn, INTEMA, Div Ceram, Res Inst Mat Sci & Technol, RA-7608 Mar Del Plata, Argentina

[3] Univ Buenos Aires, Sch Dent, Dept Oral Pathol, RA-1122 Buenos Aires, DF, Argentina

[4] Consejo Nacl Invest Cient & Tecn, Natl Res Council, RA-1033 Buenos Aires, DF, Argentina

来源：

BIOMEDICAL MATERIALS | 2006年 / 1卷 / 03期

关键词：

D O I：

10.1088/1748-6041/1/3/002

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The aim of the present study was to characterize the neoformed bone tissue around boron-modified bioactive glass particles implanted in rat tibia bone marrow by histologic, histomorphometric and microchemical evaluation. Melt-derived glasses were prepared from a base 45S5 bioactive glass of nominal composition (45% SiO2, 24.5% CaO, 24.5% Na2O and 6% P2O5 in wt%). The glass composition was modified by adding 2% wt of boron oxide (45S5.2B). Histological and histomorphometric analyses using undecalcified sections showed that at 15 days post-implantation the area of neoformed bone tissue around the 45S5.2B particles was significantly higher than control 45S5 glass. No statistically significant differences were observed at 30 days post-implantation. The thickness of osseointegrated tissue on 45S5.2B BG particles was significantly greater than on the control at all experimental time-points evaluated. A statistically significant increase in the Ca:P ratio was observed in the neoformed bone around 45S5.2B particles 15 days post-implantation. The results of the present study provide evidence that particles of boron-modified 45S5 BG ( 45S5.2B) enhance bone formation more than 45S5 glass when implanted into the intramedullary canal of rat tibiae.

引用

页码：100 / 105

页数：6

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