Effect of parenteral antibiotic administration on establishment of intestinal colonization in mice by klebsiella pneumoniae strains producing extended-spectrum β-lactamases

被引：41

作者：

Hoyen, CK

Pultz, NJ

Paterson, DL

Aron, DC

Donskey, CJ

机构：

[1] Louis Stokes Cleveland Vet Affairs Med Ctr, Infect Dis Sect, Cleveland, OH 44106 USA

[2] Louis Stokes Cleveland Vet Affairs Med Ctr, Ctr Qual Improvement Res, Cleveland, OH 44106 USA

[3] Rainbow Babies & Childrens Hosp, Cleveland, OH 44106 USA

[4] Univ Pittsburgh, Med Ctr, Div Infect Dis, Pittsburgh, PA 15261 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2003年 / 47卷 / 11期

关键词：

D O I：

10.1128/AAC.47.11.3610-3612.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A mouse model was used to test the hypothesis that antibiotics with activity against anaerobes promote overgrowth of extended-spectrum beta-lactamase-producing Klebsiella pneumoniae strains in stool. Subcutaneous clindamycin consistently promoted establishment of high-density colonization, whereas piperacillin-tazobactam, ceftriaxone, and ceftazidime promoted colonization only when a large inoculum and/or more resistant strain was administered.

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页码：3610 / 3612

页数：3

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