Association of APOE (E2, E3 and E4) gene variants and lipid levels in ischemic stroke, its subtypes and hemorrhagic stroke in a South Indian population

被引：14

作者：

Das, Satrupa ^{[1
,2
,3
]}

Kaul, Subhash ^{[4
]}

Jyothy, Akka ^{[1
,2
]}

Munshi, Anjana ^{[5
]}

机构：

[1] Osmania Univ, Inst Genet, Hyderabad 500016, Andhra Pradesh, India

[2] Osmania Univ, Hosp Genet Dis, Hyderabad 500016, Andhra Pradesh, India

[3] Dr NTR Univ Hlth Sci, Vijayawada, Andhra Pradesh, India

[4] Nizams Inst Med Sci, Hyderabad 500082, Andhra Pradesh, India

[5] Cent Univ Punjab, Sch Hlth Sci, Ctr Human Genet & Mol Med, Bathinda, Punjab, India

来源：

NEUROSCIENCE LETTERS | 2016年 / 628卷

关键词：

Ischemic stroke; Haemorrhagic stroke; TOAST classification; Lipid levels; APOE gene; APOLIPOPROTEIN-E POLYMORPHISM; INTRACEREBRAL HEMORRHAGE; CEREBROVASCULAR-DISEASE; CARDIOVASCULAR-DISEASE; CEREBRAL INFARCTION; E GENOTYPE; SUBARACHNOID HEMORRHAGE; RISK-FACTORS; METAANALYSIS; ATHEROSCLEROSIS;

D O I：

10.1016/j.neulet.2016.06.032

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

In the present study we evaluated the association of APOE (E2/E3/E4) polymorphism with ischemic stroke (n = 620), its subtypes and hemorrhagic stroke (n = 250) in a South Indian population from Telangana. The genotypes were determined using PCR-RFLP while lipid levels were measured using commercially available kits. We found significant difference in the genotypic distribution between hemorrhagic stroke patients and controls for certain genetic models [E2/E2 vs. E2/E4; E3/E3 vs. E2/E3; E3/E3 vs. E2/E4; E4/E4 vs. E2/E3; E4/E4 vs.E2/E4 and E3 vs. E4]. However, no significant difference was observed in genotypic distribution between ischemic stroke patients and controls. On analysing the genotypic distribution between ischemic and hemorrhagic stroke patients, statistically significant difference was observed in specific genetic models [E2/E2 vs. E2/E4; E3/E3 vs. E2/E3; E3/E3 vs. E2/E4; E4/E4 vs. E2/E3 and E4/E4 vs. E2/E4]. In ischemic stroke subtypes analysing for alleles E3 vs. E2 and E3 vs. E4, we found significant association with intracranial large artery (p = 0.01), cardioembolic stroke (p = 0.001 and p = 0.0004) and lacunar stroke (p = 0.02). Analysing the association of various genotypes with different lipid levels significant association was observed for VLDL (P = 0.000) and for triglyceride (P = 0.000) levels with E2/E4 and E3/E4 genotypes in ischemic stroke but not in hemorrhagic stroke. In conclusion, our results suggest that APOE polymorphism does seem to play a role in hemorrhagic stroke and also in the development of specific subtypes of ischemic stroke. Further, in ischemic stroke VLDL and triglycerides levels were found to be significantly associated with E2/E4 and E3/E4 genotypes. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

引用

页码：136 / 141

页数：6

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