Telomeric chromatin modulates replication timing near chromosome ends

被引:144
作者
Stevenson, JB
Gottschling, DE [1 ]
机构
[1] Fred Hutchinson Canc Res Ctr, Div Basic Sci, Seattle, WA 98109 USA
[2] Univ Chicago, Dept Mol Genet & Cell Biol, Chicago, IL 60637 USA
关键词
Saccharomyces cerevisiae; heterochromatin; DNA replication; telomeres; silencing;
D O I
10.1101/gad.13.2.146
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Saccharomyces cerevisiae telomeric DNA replicates late in S phase, and telomeric genes are transcriptionally silent. Transcriptional repression of telomere-proximal genes results from silent chromatin initiating at the chromosome end, but the relationship between telomeric chromatin and DNA replication is unknown. Mutations in SIR3, a silent chromatin component, cause telomeric DNA on chromosome V to replicate much earlier because of earlier initiation of a nearby replication origin, the Y' ARS. A second telomere-proximal ARS, from an X element, does not act as an origin in a wildtype strain, whereas in a sir3 cell it does. We conclude that telomeric chromatin has a Sir3-dependent inhibitory effect on DNA replication.
引用
收藏
页码:146 / 151
页数:6
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