Silica-Coated Gold Nanostars for Combined Surface-Enhanced Raman Scattering (SERS) Detection and Singlet-Oxygen Generation: A Potential Nanoplatform for Theranostics

被引：203

作者：

Fales, Andrew M. ^{[1
,2
]}

Yuan, Hsiangkuo ^{[1
,2
]}

Vo-Dinh, Tuan ^{[1
,2
,3
]}

机构：

[1] Duke Univ, Fitzpatrick Inst Photon, Durham, NC 27708 USA

[2] Duke Univ, Dept Biomed Engn, Durham, NC 27708 USA

[3] Duke Univ, Dept Chem, Durham, NC 27708 USA

来源：

LANGMUIR | 2011年 / 27卷 / 19期

基金：

美国国家卫生研究院;

关键词：

PHOTODYNAMIC THERAPY; METHYLENE-BLUE; NANOPARTICLE PLATFORMS; SPECTROSCOPY; PHOTOSENSITIZERS; PARTICLES; GROWTH; TUMORS; MICE;

D O I：

10.1021/la202602q

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

This paper reports the synthesis and characterization of surface-enhanced Raman scattering (SERS) label-tagged gold nanostars, coated with a silica shell containing methylene blue photosensitizing drug for singlet-oxygen generation. To our knowledge, this is the first report of nanocomposites possessing a combined capability for SERS detection and singlet-oxygen generation for photodynamic therapy. The gold nanostars were tuned for maximal absorption in the near-infrared (NIR) spectral region and tagged with a NIR dye for surface-enhanced resonance Raman scattering (SERRS). Silica coating was used to encapsulate the photosensitizer methylene blue in a shell around the nanoparticles. Upon 785 nm excitation, SERS from the Raman dye is observed, while excitation at 633 nm shows fluorescence from methylene blue. Methylene-blue-encapsulated nanoparticles show a significant increase in singlet-oxygen generation as compared to nanoparticles synthesized without methylene blue. This increased singlet-oxygen generation shows a cytotoxic effect on BT549 breast cancer cells upon laser irradiation. The combination of SERS detection (diagnostic) and singlet-oxygen generation (therapeutic) into a single platform provides a potential theranostic agent.

引用

页码：12186 / 12190

页数：5

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