Asymmetric approaches to 2-hydroxymethylquinuclidine derivatives

被引：14

作者：

Lygo, B ^{[1
]}

Crosby, J

Lowdon, T

Wainwright, PG

机构：

[1] Univ Salford, Dept Chem, Salford M5 4WT, Lancs, England

[2] Zeneca Pharmaceut, Macclesfield SK10 2NA, Cheshire, England

[3] Hickson & Welch Ltd, Castleford WF10 2JT, W Yorkshire, England

来源：

TETRAHEDRON | 1999年 / 55卷 / 09期

关键词：

D O I：

10.1016/S0040-4020(99)00050-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Highly enantio- and diastereoselective routes to 2-hydroxymethylquinuclidines have been developed. Key steps involve the use of Sharpless dihydroxylation or Sharpless epoxidation to introduce the asymmetry with high stereocontrol, and formation of the quinuclidine ring systems via cyclisation of epoxy amines. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：2795 / 2810

页数：16

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