The role of cytokine receptor signaling in lymphocyte development

被引：94

作者：

Baird, AM

Gerstein, RM

Berg, LJ

机构：

[1] Univ Massachusetts, Med Ctr, Dept Pathol, Worcester, MA 01655 USA

[2] Univ Massachusetts, Med Ctr, Dept Mol Genet & Microbiol, Worcester, MA 01655 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 1999年 / 11卷 / 02期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0952-7915(99)80027-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cytokine receptor signaling plays an essential role in the early stag es of lymphocyte development. Signals through various cytokine receptors - such as c-kit, flt3/flk2, CXCR4, the IL-7 receptor and the IL-15 receptor - are known to promote the expansion and survival of uncommitted progenitor cells as well as their migration to the appropriate microenvironment and subsequent differentiation into B, T or natural killer cells, The reef nt generation of mice deficient in one or more of these signaling pathways has revealed which cytokines play unique and, or redundant roles in each of these lymphocyte lineages during this developmental process.

引用

收藏

页码：157 / 166

页数：10

相关论文

共 112 条

[1] The chemokine SDF-1 is a chemoattractant for human CD34(+) hematopoietic progenitor cells and provides a new mechanism to explain the mobilization of CD34(+) progenitors to peripheral blood [J].

Aiuti, A ;

Webb, IJ ;

Bleul, C ;

Springer, T ;

GutierrezRamos, JC .

JOURNAL OF EXPERIMENTAL MEDICINE, 1997, 185 (01) :111-120

[2] Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice [J].

Akashi, K ;

Kondo, M ;

vonFreedenJeffry, U ;

Murray, R ;

Weissman, IL .

CELL, 1997, 89 (07) :1033-1041

[3]

Berkowitz RD, 1998, J IMMUNOL, V161, P3702

[4]

BILLIPS LG, 1992, BLOOD, V79, P1185

[5] The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry [J].

Bleul, CC ;

Farzan, M ;

Choe, H ;

Parolin, C ;

ClarkLewis, I ;

Sodroski, J ;

Springer, TA .

NATURE, 1996, 382 (6594) :829-833

[6] B lymphocyte chemotaxis regulated in association with microanatomic localization, differentiation state, and B cell receptor engagement [J].

Bleul, CC ;

Schultze, JL ;

Springer, TA .

JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 187 (05) :753-762

[7] The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes [J].

Bleul, CC ;

Wu, LJ ;

Hoxie, JA ;

Springer, TA ;

Mackay, CR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (05) :1925-1930

[8] Composition and function of T-cell receptor and B-cell receptor complexes an precursor lymphocytes [J].

Borst, J ;

Jacobs, H ;

Brouns, G .

CURRENT OPINION IN IMMUNOLOGY, 1996, 8 (02) :181-190

[9] IL-7 receptor and VDJ recombination: Trophic versus mechanistic actions [J].

Candeias, S ;

Muegge, K ;

Durum, SK .

IMMUNITY, 1997, 6 (05) :501-508

[10] DEFECTIVE LYMPHOID DEVELOPMENT IN MICE LACKING EXPRESSION OF THE COMMON CYTOKINE RECEPTOR-GAMMA CHAIN [J].

CAO, XQ ;

SHORES, EW ;

HULI, J ;

ANVER, MR ;

KELSALL, BL ;

RUSSELL, SM ;

DRAGO, J ;

NOGUCHI, M ;

GRINBERG, A ;

BLOOM, ET ;

PAUL, WE ;

KATZ, SI ;

LOVE, PE ;

LEONARD, WJ .

IMMUNITY, 1995, 2 (03) :223-238

← 1 2 3 4 5 6 7 8 9 10 →