Alpha-2 adrenergic receptor agonists for the treatment of attention-deficit/hyperactivity disorder: Emerging concepts from new data

被引：108

作者：

Arnsten, Amy F. ^{[1
]}

Scahill, Lawrence

Findling, Robert L.

机构：

[1] Yale Med Sch, New Haven, CT 06520 USA

[2] Ctr Child Study, Yale Med Sch, New Haven, CT USA

[3] Case Western Reserve Univ, Cleveland, OH USA

来源：

JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY | 2007年 / 17卷 / 04期

关键词：

D O I：

10.1089/cap.2006.0098

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Recent developments in the field of neuroscience have illuminated the understanding of the neural circuits impaired in attention-deficit/ hyperactivity disorder (ADHD) and the mechanism of action of treatments used to treat this condition. There is an exciting confluence between emerging studies in basic neurobiology and the genetic, neuroimaging, and neuropsychological analyses of ADHD. The following provides a brief review of this field, explaining how compounds like guanfacine and the traditional stimulant medications can reduce the core symptoms of ADHD by optimizing the neurochemical environment in the prefrontal cortex (PFC). Knowledge of these basic mechanisms may inform our medication choices and facilitate treatment of ADHD and related disorders.

引用

页码：393 / 406

页数：14

共 129 条

[1] Impairment of social and moral behavior related to early damage in human prefrontal cortex [J].