Chemical signal amplification in two-dimensional paper networks

被引：156

作者：

Fu, Elain ^{[1
]}

Kauffman, Peter ^{[1
]}

Lutz, Barry ^{[1
]}

Yager, Paul ^{[1
]}

机构：

[1] Univ Washington, Dept Bioengn, Seattle, WA 98195 USA

来源：

SENSORS AND ACTUATORS B-CHEMICAL | 2010年 / 149卷 / 01期

关键词：

Two-dimensional paper networks; Paper-based assays; Signal amplification; Gold enhancement of gold nanoparticles; IMMUNOASSAY;

D O I：

10.1016/j.snb.2010.06.024

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Two-dimensional paper networks (2DPNs) hold great potential for extending the utility of paper-based chemical and biochemical diagnostics at a cost and ease-of-use that are comparable to conventional lateral flow strips. 2DPNs enable the automated sequential delivery of multiple reagents to a detection region with a single user activation step, and therefore have the potential to extend the processing capabilities of inexpensive paper-based assays with comparable ease of use to conventional lateral flow tests. In this communication, we used a simple 3 inlet 2DPN to perform signal amplification of a colloidal gold label using a gold enhancement solution, thus demonstrating the capability of 2DPNs to perform processes that can improve limits of detection. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：325 / 328

页数：4

共 19 条

[1] Hydroxylamine seeding of colloidal Au nanoparticles in solution and on surfaces [J].