Protein Z and protein Z-dependent protease inhibitor - Determinants of levels and risk of venous thrombosis

被引：57

作者：

Al-Shanqeeti, A

Vlieg, AV

Berntorp, E

Rosendaal, FR

Broze, GJ

机构：

[1] Washington Univ, Div Haematol, St Louis, MO USA

[2] Leiden Univ, Med Ctr, Dept Clin Epidemiol & Haemostasis, Leiden, Netherlands

[3] Leiden Univ, Med Ctr, Thrombosis Res Ctr, Leiden, Netherlands

[4] Malmo Univ Hosp, Dept Coagulat Disorders, Malmo, Sweden

来源：

THROMBOSIS AND HAEMOSTASIS | 2005年 / 93卷 / 03期

关键词：

coagulation inhibitors; clinical/epidemiological studies; thrombophilia;

D O I：

10.1160/TH04-11-0715

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

To assess the potential roles of protein Z (PZ) and protein Z-dependent protease inhibitor (ZPI) in venous thrombosis, their plasma levels were measured in 426 individuals with venous thrombosis and 471 control individuals participating in the Leiden Thrombophilia Study. A relationship between the level of PZ or ZPI and venous thrombosis was not detected in the overall case-control study. PZ and ZPI circulate as a complex and their plasma levels are interdependent. Both PZ and ZPI are increased with oral contraceptive use and reduced with oral anticoagulant therapy.

引用

收藏

页码：411 / 413

页数：3

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