ATP-modulated ionic transport through synthetic nanochannels

被引：42

作者：

Ali, Mubarak ^{[1
]}

Nguyen, Quoc Hung ^{[1
]}

Neumann, Reinhard ^{[2
]}

Ensinger, Wolfgang ^{[1
]}

机构：

[1] Tech Univ Darmstadt, Fachgebiet Mat Analyt, D-64287 Darmstadt, Germany

[2] GSI Helmholtzzentrum Schwerionenforsch, Mat Forsch, D-64291 Darmstadt, Germany

来源：

CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 36期

关键词：

SOLID-STATE NANOPORES; CURRENT RECTIFICATION; NANOFLUIDIC DIODE; MITOCHONDRIAL CHANNEL; MEMBRANES; VDAC;

D O I：

10.1039/c0cc01632b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Here, we demonstrate an anion controlled molecular gate based on synthetic ion channels modified with polyethyleneimine. For single conical nanochannels, addition of ATP leads to significant decrease in the rectified ion flux, representing the closure of the ionic gate. Complementary experiments performed with nanoporous membranes show that the flux of charged dye (NDS(2-)) through a cylindrical nanochannel array diminishes by the co-addition of ATP in the analyte solution.

引用

页码：6690 / 6692

页数：3

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