Senescent cells: an emerging target for diseases of ageing

被引：914

作者：

Childs, Bennett G. ^{[1
,2
]}

Gluscevic, Martina ^{[1
,2
]}

Baker, Darren J. ^{[1
,2
,3
]}

Laberge, Remi-Martin ^{[4
]}

Marquess, Dan ^{[4
]}

Dananberg, Jamie ^{[4
]}

van Deursen, Jan M. ^{[1
,2
,3
]}

机构：

[1] Mayo Clin, Dept Biochem, 200 1st St SW, Rochester, MN 55905 USA

[2] Mayo Clin, Dept Mol Biol, 200 1st St SW, Rochester, MN 55905 USA

[3] Mayo Clin, Dept Pediat & Adolescent Med, 200 1st St SW, Rochester, MN 55905 USA

[4] Unity Biotechnol, 3280 Bayshore Blvd Suite 100, Brisbane, CA 94005 USA

来源：

NATURE REVIEWS DRUG DISCOVERY | 2017年 / 16卷 / 10期

基金：

美国国家卫生研究院;

关键词：

ONCOGENE-INDUCED SENESCENCE; CELLULAR SENESCENCE; SECRETORY PHENOTYPE; RHEUMATOID-ARTHRITIS; TUMOR SUPPRESSION; DOUBLE-BLIND; REPLICATIVE SENESCENCE; ABERRANT EXPRESSION; OSTEOARTHRITIS YEAR; PULMONARY-FIBROSIS;

D O I：

10.1038/nrd.2017.116

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

Chronological age represents the single greatest risk factor for human disease. One plausible explanation for this correlation is that mechanisms that drive ageing might also promote age-related diseases. Cellular senescence, which is a permanent state of cell cycle arrest induced by cellular stress, has recently emerged as a fundamental ageing mechanism that also contributes to diseases of late life, including cancer, atherosclerosis and osteoarthritis. Therapeutic strategies that safely interfere with the detrimental effects of cellular senescence, such as the selective elimination of senescent cells (SNCs) or the disruption of the SNC secretome, are gaining significant attention, with several programmes now nearing human clinical studies.

引用

页码：718 / 735

页数：18

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