Role of Angiopoietins and Tie receptor tyrosine kinases in angiogenesis and lymphangiogenesis

被引：230

作者：

Thurston, G ^{[1
]}

机构：

[1] Regeneron Pharmaceut Inc, Tarrytown, NY 10591 USA

来源：

CELL AND TISSUE RESEARCH | 2003年 / 314卷 / 01期

关键词：

angiopoietin; Tie2; receptor; blood vessels; lymphatic vessels; VEGF; development;

D O I：

10.1007/s00441-003-0749-6

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

This review focuses on the signaling system involving the Angiopoietin1/Tie2 receptor, which appears to be involved in the secondary stages of blood vessel formation. Although this system is crucial for blood and lymphatic vessel formation, identifying its precise role in embryonic and adult vascular biology has been a major challenge. The evidence for the key role of the Angiopoietin/Tie system is discussed, and some of the other members of the system (Ang2, Tie1) are mentioned. A comparison is made with the VEGF signaling system, which seems to provide a complementary, and somewhat more tractable, signaling system. Some of the basic unanswered questions concerning Tie/Angiopoietin biology and the secondary stages of blood vessel formation are also highlighted.

引用

页码：61 / 68

页数：8

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