Synthesis and characterisation of ibuprofen-anchored MCM-41 silica and silica gel

被引:64
作者
Tourné-Péteilh, C
Brunel, D
Bégu, S
Chiche, B
Fajula, F
Lerner, DA
Devoisselle, JM
机构
[1] ENSCM, CNRS, UMR 5618, Lab Mat Catalyt & Catalyse Chim Organ, F-34296 Montpellier 5, France
[2] UFR Sci Pharmaceut, F-34093 Montpellier 5, France
关键词
D O I
10.1039/b307046h
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A non-steroidal anti-inflammatory drug (ibuprofen) has been anchored inside the mesoporous channels of MCM-41-type silica and on a silica gel surface. The relevant anchoring procedure through an ester function has been investigated. It uses the epoxide ring opening of 3-glycidoxypropylsilane grafted on the silica surface by the carboxylic-group-containing ibuprofen. The control of the surface modification and of the anchoring efficiency was achieved by comparison of spectroscopic data with those obtained using homogeneous counterparts. The use of nano-structured silica allowed an accurate verification of the different surface modifications and also a higher drug loading.
引用
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页码:1415 / 1418
页数:4
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