A brief history of T cell help to B cells

被引:370
作者
Crotty, Shane [1 ]
机构
[1] La Jolla Inst Allergy & Immunol, Div Vaccine Discovery, San Diego, CA 92037 USA
关键词
X-LINKED IMMUNODEFICIENCY; CXC CHEMOKINE RECEPTOR-5; HEMOLYSIN-FORMING CELLS; CD40; LIGAND; CUTTING EDGE; IMMUNE-RESPONSE; DEFECTIVE EXPRESSION; HUMORAL IMMUNITY; MEMORY B; BCL6;
D O I
10.1038/nri3803
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
In celebration of the 50th anniversary of the discovery of B cells, I take a look back at the history of T cell help to B cells, which was discovered 47 years ago. In addition, I summarize and categorize the distinct molecules that are expressed by CD4(+)T cells that constitute 'help' to B cells, and particularly the molecules expressed by T follicular helper (T-FH) cells, which are the specialized providers of help to B cells.
引用
收藏
页码:185 / 189
页数:5
相关论文
共 85 条
[1]   Germinal-center organization and cellular dynamics [J].
Allen, Christopher D. C. ;
Okada, Takaharu ;
Cyster, Jason G. .
IMMUNITY, 2007, 27 (02) :190-202
[2]   CD40 LIGAND GENE DEFECTS RESPONSIBLE FOR X-LINKED HYPER-IGM SYNDROME [J].
ALLEN, RC ;
ARMITAGE, RJ ;
CONLEY, ME ;
ROSENBLATT, H ;
JENKINS, NA ;
COPELAND, NG ;
BEDELL, MA ;
EDELHOFF, S ;
DISTECHE, CM ;
SIMONEAUX, DK ;
FANSLOW, WC ;
BELMONT, J ;
SPRIGGS, MK .
SCIENCE, 1993, 259 (5097) :990-993
[3]   A chemokine-driven positive feedback loop organizes lymphoid follicles [J].
Ansel, KM ;
Ngo, VN ;
Hyman, PL ;
Luther, SA ;
Förster, R ;
Sedgwick, JD ;
Browning, JL ;
Lipp, M ;
Cyster, JG .
NATURE, 2000, 406 (6793) :309-314
[4]   MOLECULAR AND BIOLOGICAL CHARACTERIZATION OF A MURINE LIGAND FOR CD40 [J].
ARMITAGE, RJ ;
FANSLOW, WC ;
STROCKBINE, L ;
SATO, TA ;
CLIFFORD, KN ;
MACDUFF, BM ;
ANDERSON, DM ;
GIMPEL, SD ;
DAVISSMITH, T ;
MALISZEWSKI, CR ;
CLARK, EA ;
SMITH, CA ;
GRABSTEIN, KH ;
COSMAN, D ;
SPRIGGS, MK .
NATURE, 1992, 357 (6373) :80-82
[5]   THE CD40 LIGAND, GP39, IS DEFECTIVE IN ACTIVATED T-CELLS FROM PATIENTS WITH X-LINKED HYPER-IGM SYNDROME [J].
ARUFFO, A ;
FARRINGTON, M ;
HOLLENBAUGH, D ;
LI, X ;
MILATOVICH, A ;
NONOYAMA, S ;
BAJORATH, J ;
GROSMAIRE, LS ;
STENKAMP, R ;
NEUBAUER, M ;
ROBERTS, RL ;
NOELLE, RJ ;
LEDBETTER, JA ;
FRANCKE, U ;
OCHS, HD .
CELL, 1993, 72 (02) :291-300
[6]   B cell-intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans [J].
Avery, Danielle T. ;
Deenick, Elissa K. ;
Ma, Cindy S. ;
Suryani, Santi ;
Simpson, Nicholas ;
Chew, Gary Y. ;
Chan, Tyani D. ;
Palendira, Umamainthan ;
Bustamante, Jacinta ;
Boisson-Dupuis, Stephanie ;
Choo, Sharon ;
Bleasel, Karl E. ;
Peake, Jane ;
King, Cecile ;
French, Martyn A. ;
Engelhard, Dan ;
Al-Hajjar, Sami ;
Al-Muhsen, Saleh ;
Magdorf, Klaus ;
Roesler, Joachim ;
Arkwright, Peter D. ;
Hissaria, Pravin ;
Riminton, D. Sean ;
Wong, Melanie ;
Brink, Robert ;
Fulcher, David A. ;
Casanova, Jean-Laurent ;
Cook, Matthew C. ;
Tangye, Stuart G. .
JOURNAL OF EXPERIMENTAL MEDICINE, 2010, 207 (01) :155-171
[7]   Cutting Edge: Distinct Waves of BCL6 Expression during T Follicular Helper Cell Development [J].
Baumjohann, Dirk ;
Okada, Takaharu ;
Ansel, K. Mark .
JOURNAL OF IMMUNOLOGY, 2011, 187 (05) :2089-2092
[8]   Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production [J].
Breitfeld, D ;
Ohl, L ;
Kremmer, E ;
Ellwart, J ;
Sallusto, F ;
Lipp, M ;
Förster, R .
JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 192 (11) :1545-1551
[9]   SAP regulates T cell-mediated help for humoral immunity by a mechanism distinct from cytokine regulation [J].
Cannons, Jennifer L. ;
Yu, Li J. ;
Jankovic, Dragana ;
Crotty, Shane ;
Horai, Reiko ;
Kirby, Martha ;
Anderson, Stacie ;
Cheever, Allen W. ;
Sher, Alan ;
Schwartzberg, Pamela L. .
JOURNAL OF EXPERIMENTAL MEDICINE, 2006, 203 (06) :1551-1565
[10]   SLAM Family Receptors and SAP Adaptors in Immunity [J].
Cannons, Jennifer L. ;
Tangye, Stuart G. ;
Schwartzberg, Pamela L. .
ANNUAL REVIEW OF IMMUNOLOGY, VOL 29, 2011, 29 :665-705