A brief history of T cell help to B cells

被引：370

作者：

Crotty, Shane ^{[1
]}

机构：

[1] La Jolla Inst Allergy & Immunol, Div Vaccine Discovery, San Diego, CA 92037 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2015年 / 15卷 / 03期

关键词：

X-LINKED IMMUNODEFICIENCY; CXC CHEMOKINE RECEPTOR-5; HEMOLYSIN-FORMING CELLS; CD40; LIGAND; CUTTING EDGE; IMMUNE-RESPONSE; DEFECTIVE EXPRESSION; HUMORAL IMMUNITY; MEMORY B; BCL6;

D O I：

10.1038/nri3803

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In celebration of the 50th anniversary of the discovery of B cells, I take a look back at the history of T cell help to B cells, which was discovered 47 years ago. In addition, I summarize and categorize the distinct molecules that are expressed by CD4(+)T cells that constitute 'help' to B cells, and particularly the molecules expressed by T follicular helper (T-FH) cells, which are the specialized providers of help to B cells.

引用

页码：185 / 189

页数：5

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