Cytokine production and adhesive protein expression by endothelial cells after contact with polyethylene terephthalate

被引：19

作者：

Cenni, E ^{[1
]}

Granchi, D ^{[1
]}

Ciapetti, G ^{[1
]}

Verri, E ^{[1
]}

Cavedagna, D ^{[1
]}

Gamberini, S ^{[1
]}

DiLeo, A ^{[1
]}

Pizzoferrato, A ^{[1
]}

机构：

[1] POLICLIN S ORSOLA,IST FISIOPATOL RIPROD,BOLOGNA,ITALY

来源：

BIOMATERIALS | 1996年 / 17卷 / 21期

关键词：

endothelial cells; adhesive protein; cytokine; polyethylene terephthalate;

D O I：

10.1016/0142-9612(96)00037-3

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The authors have evaluated adhesive protein expression and cytokine production by human umbilical vein endothelial cells cultured in contact with polyethylene terephthalate (PET). ELAM-1, ICAM-1 and VGAM-1 expression was determined by flow cytometry; the concentration of interleukin-1 alpha (IL-1 alpha), interleukin-6 (IL-6), granulocyte colony stimulating factor (G-CSF) and granulocyte-macrophage colony stimulating factor (GM-CSF) in the supernatant was determined by enzyme immunoassay. The contact with PET determined a significant increase in ELAM-1 expression and insignificant increase in cytokine production, demonstrating that PET had a limited capability to stimulate endothelial cells in a pro-inflammatory sense. (C) 1996 Elsevier Science Limited

引用

页码：2071 / 2076

页数：6

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