Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes

被引：484

作者：

Venugopal, R ^{[1
]}

Jaiswal, AK ^{[1
]}

机构：

[1] Baylor Coll Med, Dept Pharmacol, Houston, TX 77030 USA

来源：

ONCOGENE | 1998年 / 17卷 / 24期

关键词：

NF-E2 related factors; Jun; antioxidant response element; regulation of expression; detoxifying enzyme genes;

D O I：

10.1038/sj.onc.1202237

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Antioxidant response element (ARE)-mediated expression and coordinated induction of genes encoding detoxifying enzymes is one mechanism of critical importance to cellular protection against oxidative stress. In the present report, we demonstrate that nuclear transcription factors Nrf2 and Nrf1 associate with Jun (c-Jun, Jun-B and Jun-D) proteins to upregulate ARE-mediated expression and coordinated induction of detoxifying enzymes in response to antioxidants and xenobiotics. Nrf-Jun association/heterodimerization and binding to the ARE required unknown cytosolic factor(s), Nrf2 containing one mutated leucine in its leucine zipper region was more efficient in upregulation of ARE-mediated gene expression, as compared to Nrf1 with two mutated leucines.

引用

页码：3145 / 3156

页数：12

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