Birth after intracytoplasmic sperm injection with use of testicular sperm from men with Kartagener/immotile cilia syndrome

Objective: To describe two cases of in vitro fertilization (TVF) and intracytoplasmic sperm injection (ICSI) with testicular sperm in men with immotile cilia syndromes. Design: Case report. Setting: A university-based male infertility clinic and assisted reproduction unit. Patient(s): Two couples with male factor infertility due to Kartagener/immotile cilia syndrome. Intervention(s): IVF/ICSI with testicular sperm. Main outcome measure(s): Semen characteristics, sperm viability, fertilization rate, and pregnancy. Result(s): With testicular sperm, the two pronuclear fertilization rates were 63% and 60% in two cases. One case resulted in the birth of normal healthy girl. Conclusion(s): With testicular sperm, successful oocyte fertilization after ICSI in couples with male Kartagener/immotile cilia syndrome is possible despite the lack of sperm motility. (Fertil Steril(R) 2001;76:612-14. (C) 2001 by American Society for Reproductive Medicine).