Self-Assembled Multivalency: Dynamic Ligand Arrays for High-Affinity Binding

被引：151

作者：

Barnard, Anna ^{[1
]}

Smith, David K. ^{[1
]}

机构：

[1] Univ York, Dept Chem, York YO10 5DD, N Yorkshire, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 27期

关键词：

molecular recognition; multivalency; non-covalent interactions; self-assembly; supramolecular chemistry; GOLD GLYCONANOPARTICLES; INTEGRIN ALPHA(V)BETA(3); SUPRAMOLECULAR CHEMISTRY; BIOMEDICAL APPLICATIONS; AMPHIPHILIC DENDRIMERS; GENE DELIVERY; DNA-BINDING; RECOGNITION; SURFACE; NANOPARTICLES;

D O I：

10.1002/anie.201200076

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Multivalency is a powerful strategy for achieving high-affinity molecular recognition in biological systems. Recently, attention has begun to focus on using self-assembly rather than covalent scaffold synthesis to organize multiple ligands. This approach has a number of advantages, including ease of synthesis/assembly, tunability of nanostructure morphology and ligands, potential to incorporate multiple active units, and the responsive nature of self-assembly. We suggest that self-assembled multivalency is a strategy of fundamental importance in the design of synthetic nanosystems to intervene in biological pathways and has potential applications in nanomedicine. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：6572 / 6581

页数：10

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