Redox regulation by glutathione needs enzymes

被引：76

作者：

Berndt, Carsten ^{[1
]}

Lillig, Christopher H. ^{[2
]}

Flohe, Leopold ^{[3
,4
]}

机构：

[1] Univ Dusseldorf, Fac Med, Dept Neurol, Dusseldorf, Germany

[2] Ernst Moritz Arndt Univ Greifswald, Univ Med, Inst Med Biochem & Mol Biol, Greifswald, Germany

[3] Univ Republica, Dept Bioquim, Montevideo, Uruguay

[4] Univ Padua, Dept Chem, Padua, Italy

来源：

FRONTIERS IN PHARMACOLOGY | 2014年 / 5卷

关键词：

glutathione; thermodynamics; kinetics; enzyme; redox signaling; ADENOSINE TRIPHOSPHATE CONSERVATION; KAPPA-B ACTIVATION; OXIDATIVE STRESS; CELL-DEATH; HYDROGEN-PEROXIDE; ESCHERICHIA-COLI; THIOL; GLUTAREDOXIN; OVEREXPRESSION; REDUCTASE;

D O I：

10.3389/fphar.2014.00168

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

The GSH/GSSG redox potential has become a fashionable electrochemical parameter believed to be a major driving force of redox reactions regulating biological events (Schafer and Buettner, 2001; Jones, 2006; Blanco et al., 2007; Chaiswing et al., 2012). Here, we will challenge this concept, because we consider it an untenable simplification that ignores kinetic constrains and detracts the attention from more important, though more complex, catalytic events. The focus of this article is the importance of reaction kinetics vs. thermodynamics in the redox regulation of biological systems. © 2014 Berndt, Lillig and Flohé.

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