A convergence theorem for Markov chains arising in population genetics and the coalescent with selfing

被引:66
作者
Mohle, M
机构
[1] Univ Chicago, Dept Stat, Chicago, IL 60637 USA
[2] Univ Mainz, Fachbereich Math, D-55099 Mainz, Germany
关键词
coalescent; diploid population models; genealogical process; population genetics; robustness; selfing;
D O I
10.1239/aap/1035228080
中图分类号
O21 [概率论与数理统计]; C8 [统计学];
学科分类号
020208 ; 070103 ; 0714 ;
摘要
A simple convergence theorem for sequences of Markov chains is presented in order to derive new 'convergence-to-the-coalescent' results for diploid neutral population models. For the so-called diploid Wright-Fisher model with selfing probability s and mutation rate theta, it is shown that the ancestral structure of n sampled genes can be treated in the framework of an n-coalescent with mutation rate <(theta)over tilde> := theta(1 - s/2), if the population size N is large and if the time is measured in units of (2 - s)N generations.
引用
收藏
页码:493 / 512
页数:20
相关论文
共 15 条
  • [1] Brown A. H. D., 1990, Plant population genetics, breeding, and genetic resources., P145
  • [2] MEASURING PLANT MATING SYSTEMS
    CLEGG, MT
    [J]. BIOSCIENCE, 1980, 30 (12) : 814 - 818
  • [3] Coalescents and genealogical structure under neutrality
    Donnelly, P
    Tavare, S
    [J]. ANNUAL REVIEW OF GENETICS, 1995, 29 : 401 - 421
  • [4] Griffiths RC, 1997, PROGR POPULATION GEN, P257
  • [5] HUDSON RR, 1988, GENETICS, V120, P831
  • [6] Kingman J.F., 1982, J. Appl. Probab., P27, DOI [DOI 10.2307/3213548, 10.2307/3213548]
  • [7] Kingman J.F., 1982, Stochastic Process. Appl., V13, P235, DOI [DOI 10.1016/0304-4149(82)90011-4, 10.1016/0304-4149(82)90011-4]
  • [8] Kingman J.F. C., 1982, EXCHANGEABILITY PROB, P97
  • [9] Milligan BG, 1996, GENETICS, V142, P619
  • [10] Coalescent results for two-sex population models
    Mohle, M
    [J]. ADVANCES IN APPLIED PROBABILITY, 1998, 30 (02) : 513 - 520