DSCAM, a highly conserved gene in mammals, expressed in differentiating mouse brain

被引：43

作者：

Agarwala, KL ^{[1
]}

Ganesh, S ^{[1
]}

Amano, K ^{[1
]}

Suzuki, T ^{[1
]}

Yamakawa, K ^{[1
]}

机构：

[1] RIKEN, Brain Sci Inst, Neurogenet Lab, Wako, Saitama 3510198, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2001年 / 281卷 / 03期

关键词：

DSCAM; mouse; immunoglobulin superfamily; cell adhesion molecule; development; expression; Down syndrome;

D O I：

10.1006/bbrc.2001.4420

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Down Syndrome Cell Adhesion molecule (DSCAM) is a member of the immunoglobulin superfamily, and represents a novel class of neuronal cell adhesion molecules. In order to understand the cellular functions of DSCAM, we isolated full-length mouse and human cDNA clones, and analysed its expression during mouse development and differentiation. Sequence analysis of the human DSCAM cDNA predicted at least 33 exons that are distributed over 840 kb. When compared to human DSCAM, the mouse homologue showed 90 and 98% identity at the nucleotide and amino acid levels, respectively. In mouse, DSCAM is located on 16C, the syntenic region for human chromosome band 21q22 and also the region duplicated in mouse DS models. DSCAM gene is predicted to encode an similar to 220-kDa protein, and its expression shows dynamic changes that correlate with neuronal differentiation during mouse development. Our results suggest that DSCAM may play critical roles in the formation and maintenance of specific neuronal networks in brain, (C) 2001 Academic Press.

引用

页码：697 / 705

页数：9

共 31 条

[1] Down syndrome cell adhesion molecule DSCAM mediates homophilic intercellular adhesion [J].

Agarwala, KL ;

Nakamura, S ;

Tsutsumi, Y ;

Yamakawa, K .

MOLECULAR BRAIN RESEARCH, 2000, 79 (1-2) :118-126

[2] 10 years of genomics, chromosome 21, and Down syndrome [J].

Antonarakis, SE .

GENOMICS, 1998, 51 (01) :1-16

[3] Cerebellar volume in adults with Down syndrome [J].

Aylward, EH ;

Habbak, R ;

Warren, AC ;

Pulsifer, MB ;

Barta, PE ;

Jerram, M ;

Pearlson, GD .

ARCHIVES OF NEUROLOGY, 1997, 54 (02) :209-212

[4] CONSERVED REGULATORY ELEMENTS IN THE PROMOTER REGION OF THE N-CAM GENE [J].

COLWELL, G ;

LI, B ;

FORREST, D ;

BRACKENBURY, R .

GENOMICS, 1992, 14 (04) :875-882

[5]

CROME L, 1966, J MENT DEFIC RES, V10, P69

[6] NEURAL CELL-ADHESION MOLECULE - STRUCTURE, IMMUNOGLOBULIN-LIKE DOMAINS, CELL-SURFACE MODULATION, AND ALTERNATIVE RNA SPLICING [J].

CUNNINGHAM, BA ;

HEMPERLY, JJ ;

MURRAY, BA ;

PREDIGER, EA ;

BRACKENBURY, R ;

EDELMAN, GM .

SCIENCE, 1987, 236 (4803) :799-806

[7] The brain in Mongolian idiocy - A report of ten cases [J].

Davidoff, LM .

ARCHIVES OF NEUROLOGY AND PSYCHIATRY, 1928, 20 (06) :1229-1257

[8] THE GENE OF CHICKEN AXONIN-1 - COMPLETE STRUCTURE AND ANALYSIS OF THE PROMOTER [J].

GIGER, RJ ;

VOGT, L ;

ZUELLIG, RA ;

RADER, C ;

HENEHANBEATTY, A ;

WOLFER, DP ;

SONDEREGGER, P .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1995, 227 (03) :617-628

[9] NEURON-GLIA CELL-ADHESION MOLECULE INTERACTS WITH NEURONS AND ASTROGLIA VIA DIFFERENT BINDING MECHANISMS [J].

GRUMET, M ;

EDELMAN, GM .

JOURNAL OF CELL BIOLOGY, 1988, 106 (02) :487-503

[10] The DNA sequence of human chromosome 21 [J].

Hattori, M ;

Fujiyama, A ;

Taylor, TD ;

Watanabe, H ;

Yada, T ;

Park, HS ;

Toyoda, A ;

Ishii, K ;

Totoki, Y ;

Choi, DK ;

Soeda, E ;

Ohki, M ;

Takagi, T ;

Sakaki, Y ;

Taudien, S ;

Blechschmidt, K ;

Polley, A ;

Menzel, U ;

Delabar, J ;

Kumpf, K ;

Lehmann, R ;

Patterson, D ;

Reichwald, K ;

Rump, A ;

Schillhabel, M ;

Schudy, A ;

Zimmermann, W ;

Rosenthal, A ;

Kudoh, J ;

Shibuya, K ;

Kawasaki, K ;

Asakawa, S ;

Shintani, A ;

Sasaki, T ;

Nagamine, K ;

Mitsuyama, S ;

Antonarakis, SE ;

Minoshima, S ;

Shimizu, N ;

Nordsiek, G ;

Hornischer, K ;

Brandt, P ;

Scharfe, M ;

Schön, O ;

Desario, A ;

Reichelt, J ;

Kauer, G ;

Blöcker, H ;

Ramser, J ;

Beck, A .

NATURE, 2000, 405 (6784) :311-319

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