Demystifying FluMist, a new intranasal, live influenza vaccine

被引：31

作者：

Mossad, SB ^{[1
]}

机构：

[1] Cleveland Clin Fdn, Dept Infect Dis, Cleveland, OH 44195 USA

来源：

CLEVELAND CLINIC JOURNAL OF MEDICINE | 2003年 / 70卷 / 09期

关键词：

D O I：

10.3949/ccjm.70.9.801

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

FluMist-a cold-adapted, live-attenuated, trivalent, intranasal influenza virus vaccine approved by the US Food and Drug Administration on June 17, 2003-has been shown to be safe and effective, but its role in the general prevention of influenza is yet to be defined. Intranasal administration is expected to be more acceptable than parenteral, particularly in children, but the potential for the shedding of live virus may pose a risk to anyone with a compromised immune system.

引用

页码：801 / 806

页数：6

共 49 条

[1] Efficacy of vaccination with live attenuated, cold-adapted, trivalent, intranasal influenza virus vaccine against a variant (A/Sydney) not contained in the vaccine
Belshe, RB
Gruber, WC
Mendelman, PM
Cho, I
Reisinger, K
Block, SL
Wittes, J
Iacuzio, D
Piedra, P
Treanor, J
King, J
Kotloff, K
Bernstein, DI
Hayden, FG
Zangwill, K
Yan, LH
Wolff, M
[J]. JOURNAL OF PEDIATRICS, 2000, 136 (02) : 168 - 175
[2] The efficacy of live attenuated, cold-adapted, trivalent, intranasal influenzavirus vaccine in children
Belshe, RB
Mendelman, PM
Treanor, J
King, J
Gruber, WC
Piedra, P
Bernstein, DI
Hayden, FG
Kotloff, K
Zangwill, K
Iacuzio, D
Wolff, M
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1998, 338 (20) : 1405 - 1412
[3] Effect of yearly vaccinations with live, attenuated, cold-adapted, trivalent, intranasal influenza vaccines on antibody responses in children
Bernstein, DI
Yan, LH
Treanor, J
Mendelman, PM
Belshe, R
[J]. PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2003, 22 (01) : 28 - 34
[4] Cold-adapted live influenza vaccine versus inactivated vaccine: systemic vaccine reactions, local and systemic antibody response, and vaccine efficacy A meta-analysis
Beyer, WEP
Palache, AM
de Jong, JC
Osterhaus, ADME
[J]. VACCINE, 2002, 20 (9-10) : 1340 - 1353
[5] Mucosal immune response to trivalent live attenuated intranasal influenza vaccine in children
Boyce, TG
Gruber, WC
Coleman-Dockery, SD
Sannella, EC
Reed, GW
Wolff, M
Wright, PF
[J]. VACCINE, 1999, 18 (1-2) : 82 - 88
[6] Bridges Carolyn B, 2003, MMWR Recomm Rep, V52, P1
[7] Parenteral vaccination against influenza does not induce a local antigen-specific immune response in the nasal mucosa
Brokstad, KA
Eriksson, JC
Cox, RJ
Tynning, T
Olofsson, J
Jonsson, R
Davidsson, Å
[J]. JOURNAL OF INFECTIOUS DISEASES, 2002, 185 (07) : 878 - 884
[8] Influenza burden of illness - Estimates from a national prospective survey of household contacts in France
Carrat, F
Sahler, C
Rogez, S
Leruez-Ville, M
Freymuth, F
Le Gales, C
Bungener, M
Housset, B
Nicolas, M
Rouzioux, C
[J]. ARCHIVES OF INTERNAL MEDICINE, 2002, 162 (16) : 1842 - 1848
[9] A RANDOMIZED CONTROLLED TRIAL OF COLD-ADAPTED AND INACTIVATED VACCINES FOR THE PREVENTION OF INFLUENZA A DISEASE
EDWARDS, KM
DUPONT, WD
WESTRICH, MK
PLUMMER, WD
PALMER, PS
WRIGHT, PF
[J]. JOURNAL OF INFECTIOUS DISEASES, 1994, 169 (01) : 68 - 76
[10] The role of live influenza vaccines in children
Gruber, WC
[J]. VACCINE, 2002, 20 : S66 - S73

← 1 2 3 4 5 →