Carotid ultrasonography for detection of vascular abnormalities in hypertensive children

被引:84
作者
Sorof, JM
Alexandrov, AV
Garami, Z
Turner, JL
Grafe, RE
Lai, DJ
Portman, RJ
机构
[1] Univ Texas, Sch Med, Div Pediat Nephrol & Hypertens, Houston, TX 77030 USA
[2] Univ Texas, Hlth Sci Ctr, Dept Pediat, Div Nephrol & Hypertens, Houston, TX 77225 USA
[3] Univ Texas, Hlth Sci Ctr, Dept Neurol, Houston, TX 77225 USA
[4] Univ Texas, Hlth Sci Ctr, Sch Publ Hlth, Dept Biometry, Houston, TX USA
关键词
hypertension; carotid ultrasonography; intimal-medial thickness; atherosclerosis;
D O I
10.1007/s00467-003-1187-0
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
To determine whether hypertension and overweight status are associated with increased carotid intimal-medial thickness (cIMT) in children, vascular ultrasonography was performed in newly diagnosed hypertensive patients (n=53) and normotensive controls (n=33). Hypertensive subjects were identified either by referral or by systematic school-based hypertension screening. Hypertension was defined as blood pressure above the 95th percentile based on current Task Force criteria, and overweight was defined as body mass index (BMI) >25 kg/m(2). cIMT was assessed by high-resolution vascular ultrasonography of the distal common carotid artery. Hypertensive subjects had a higher cIMT than normotensive subjects (0.62 vs. 0.53 mm, P<0.00001). This difference remained significant after controlling for the effects of gender, race, age, height, weight, and BMI. Similarly, overweight subjects had a higher cIMT than normal-weight subjects (0.63 vs. 0.54 mm, P<0.0001). Subjects with both systolic and diastolic hypertension had higher cIMT than those with isolated systolic hypertension (0.67 vs. 0.60, P<0.05). cIMT showed significant positive pairwise correlation with age, height, weight, BMI, and systolic blood pressure. Among all clinical variables analyzed, cIMT was most strongly correlated with BMI (r=0.53, P<0.001). These results provide further evidence that vasculopathy occurs in association with known cardiovascular risk factors such as hypertension and obesity during childhood.
引用
收藏
页码:1020 / 1024
页数:5
相关论文
共 29 条
[1]  
[Anonymous], 1992, AM J HYPERTENS, V5, P207
[2]   Influence of diurnal blood pressure variations on target organ abnormalities in adolescents with mild essential hypertension [J].
Belsha, CW ;
Wells, TG ;
NcNiece, KL ;
Seib, PM ;
Plummer, JK ;
Berry, PL .
AMERICAN JOURNAL OF HYPERTENSION, 1998, 11 (04) :410-417
[3]   Association between multiple cardiovascular risk factors and atherosclerosis in children and young adults [J].
Berenson, GS ;
Srinivasan, SR ;
Bao, WH ;
Newman, WP ;
Tracy, RE ;
Wattigney, WA .
NEW ENGLAND JOURNAL OF MEDICINE, 1998, 338 (23) :1650-1656
[4]   CARDIAC STATUS IN JUVENILE BORDERLINE HYPERTENSION [J].
CULPEPPER, WS ;
SODT, PC ;
MESSERLI, FH ;
RUSCHHAUPT, DG ;
ARCILLA, RA .
ANNALS OF INTERNAL MEDICINE, 1983, 98 (01) :1-7
[6]   DETERMINANTS OF CARDIAC INVOLVEMENT IN CHILDREN AND ADOLESCENTS WITH ESSENTIAL-HYPERTENSION [J].
DANIELS, SD ;
MEYER, RA ;
LOGGIE, JMH .
CIRCULATION, 1990, 82 (04) :1243-1248
[7]   Left ventricular geometry and severe left ventricular hypertrophy in children and adolescents with essential hypertension [J].
Daniels, SR ;
Loggie, JMH ;
Khoury, P ;
Kimball, TR .
CIRCULATION, 1998, 97 (19) :1907-1911
[8]   CORONARY DISEASE AMONG UNITED-STATES SOLDIERS KILLED IN ACTION IN KOREA [J].
ENOS, WF ;
HOLMES, RH ;
BEYER, J .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1953, 152 (12) :1090-1093
[9]  
Falkner B, 1996, PEDIATRICS, V98, P649
[10]  
GOLDRING D, 1979, J PEDIATR-US, V95, P298