Effect of a 17α-(3-hydroxypropyl)-17β-acetyl substituent pattern on the glucocorticoid and progestin receptor binding of 11β-arylestra-4,9-dien-3-ones

被引：8

作者：

Cook, CE ^{[1
]}

Raje, P ^{[1
]}

Lee, DYW ^{[1
]}

Kepler, JA ^{[1
]}

机构：

[1] Res Triangle Inst, Res Triangle Pk, NC 27709 USA

来源：

ORGANIC LETTERS | 2001年 / 3卷 / 07期

关键词：

D O I：

10.1021/ol007067b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Replacing the 17 alpha -acetoxy substituent in an antiprogestational 17 beta -acetyl-11 beta -arylestra-4,9-dien-3-one by 9-hydroxypropyl significantly diminished glucocorticoid receptor binding with little effect on progestin receptor binding.

引用

页码：1013 / 1016

页数：4

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