Expanded micro-particles by supercritical antisolvent precipitation: Interpretation of results

被引：54

作者：

Reverchon, E. ^{[1
]}

De Marco, I. ^{[1
]}

Adami, R. ^{[1
]}

Caputo, G. ^{[1
]}

机构：

[1] Univ Salerno, Dipartimento Ingn Chim & Alimentare, I-84084 Fisciano, SA, Italy

来源：

JOURNAL OF SUPERCRITICAL FLUIDS | 2008年 / 44卷 / 01期

关键词：

expanded micro-particles; supercritical antisolvent precipitation; drugs; catalysts precursors; colouring matters; polymers; COMPRESSED FLUID ANTISOLVENT; SUPERCONDUCTOR PRECURSORS; PARTICLE FORMATION; MASS-TRANSFER; PCA PROCESS; NANOPARTICLES; MICRONIZATION; ATOMIZATION; EQUILIBRIA; MECHANISM;

D O I：

10.1016/j.supflu.2007.08.008

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Supercritical antisolvent (SAS) micronization has been used to obtain nanoparticles and micro-particles of several kinds of materials. Sometimes hollow expanded micro-particles have also been obtained. This work is focused on the analysis of this last morphology. We organized literature data and our previous experiments and we added new experiments on previously tested compounds and on compounds never tested before. As a result, expanded micro-particles using several compounds belonging to different categories and precipitated from different solvents in laboratory and pilot scale plants were obtained with diameters between about 10 and 180 mu m. They also showed different sub-structures: uniform or nanostructured surface or constituted by microcrystals. Also expanded micro-particles of coprecipitates were obtained. To explain all the available experimental evidences, we propose a mechanism of hollow expanded micro-particles formation, based on thermodynamic and mass transfer interactions. (c) 2007 Elsevier B.V. All rights reserved.

引用

页码：98 / 108

页数：11

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