Mechanisms of N-demethylations catalyzed by high-valent species of heme enzymes: Novel use of isotope effects and direct observation of intermediates

被引：87

作者：

Goto, Y

Watanabe, Y ^{[1
]}

Fukuzumi, S

Jones, JP

Dinnocenzo, JP

机构：

[1] Grad Univ Adv Studies, Dept Struct Mol Sci, Okazaki, Aichi 4448585, Japan

[2] Inst Mol Sci, Okazaki, Aichi 4448585, Japan

[3] Osaka Univ, Dept Appl Chem, Suita, Osaka 565, Japan

[4] Univ Rochester, Dept Pharmacol, Rochester, NY 14642 USA

[5] Univ Rochester, Dept Chem, Rochester, NY 14642 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1998年 / 120卷 / 41期

关键词：

D O I：

10.1021/ja981357u

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

引用

页码：10762 / 10763

页数：2

共 15 条

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[6] Evidence for a 1-electron oxidation mechanism in N-dealkylation of N,N-dialkylanilines by cytochrome P450 2B1 - Kinetic hydrogen isotope effects, linear free energy relationships, comparisons with horseradish peroxidase, and studies with oxygen surrogates
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[7] CHEMICAL MECHANISMS OF CATALYSIS BY CYTOCHROMES-P-450 - A UNIFIED VIEW
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[8] KARKI SB, 1995, J AM CHEM SOC, V117, P3657, DOI 10.1021/ja00118a001
[9] KEDDERIS GL, 1980, J BIOL CHEM, V255, P174
[10] KEDDERIS GL, 1983, J BIOL CHEM, V258, P8129

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