Report of the WHO working group on the assessment of health risks for human infants from exposure to PCDDs, PCDFs and PCBs.

被引:87
作者
Brouwer, A
Ahlborg, UG
van Leeuwen, FXR
Feeley, MM
机构
[1] Wageningen Univ Agr, Dept Toxicol, NL-6700 EA Wageningen, Netherlands
[2] Karolinska Inst, Inst Environm Med, S-17177 Stockholm, Sweden
[3] European Ctr Environm Hlth, Bilthoven Div, NL-3730 AA Bilthoven, Netherlands
[4] Hlth Canada, Hlth Protect Branch, Bur Chem Safety, Ottawa, ON K1A 0L2, Canada
关键词
D O I
10.1016/S0045-6535(98)00230-6
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
On Nov. 20-22, 1995, a World Health Organization working group consisting of 12 scientific representatives from 6 different countries met to reassess the health risks to infants associated with perinatal exposure to polyhalogenated aromatic hydrocarbons (PHAHs). Following a review of previous WHO/EURO consultations, as part of their comprehensive programme on PCDDs, PCDFs and PCBs, current exposure information and recent experimental and epidemiologic data were discussed. Exposure assessments within the past decade have revealed that in the case of breast milk samples concentrations of PCDDs/DFs and PCBs have shown a continual decline, in certain countries by up to 50%. New experimental data has revealed that a variety of structural, functional and behaviourial alterations can be induced in rodent species following exposure to PHAHs while a Dutch collaborative PCB/dioxin study has illustrated subtle clinical, endocrine and mental/psychomotor development effects can occur in breast fed infants. The provisional conclusions of the working group were: 1) current evidence does not warrant altering the previous WHO recommendation for promotion/support of breast feeding and 2) based on new clinical data which supports the biological plausibility of certain observed experimental observations, continued and enhanced effort should be directed towards identifying and controlling sources of environmental input for these contaminants. (C) 1998 Elsevier Science Ltd. All rights reserved.
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页码:1627 / 1643
页数:17
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