Total synthesis of both enantiomers of the macrocyclic lactone citreofuran

被引：10

作者：

Bracher, F ^{[1
]}

Schulte, B ^{[1
]}

机构：

[1] Univ Munich, Dept Pharm, Zentrum Pharmaforsch, D-81377 Munich, Germany

来源：

NATURAL PRODUCT RESEARCH | 2003年 / 17卷 / 04期

关键词：

citreofuran; enantioselective synthesis; lipase; lactonization; cross-coupling;

D O I：

10.1080/1478641031000137004

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Both enantiomers of the polyketide-derived lactone citreofuran (4) have been prepared. The enantiopure building blocks were obtained on a chemoenzymatic route ((S)-6) and by a chiral pool synthesis ((R)-6). The crucial step in the synthesis, a macrolactonization, was accomplished under Mitsunobu conditions.

引用

页码：293 / 299

页数：7

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