MinK-related peptide 1 -: A β subunit for the HCN ion channel subunit family enhances expression and speeds activation

被引：181

作者：

Yu, H

Wu, J

Potapova, I

Wymore, RT

Holmes, B

Zuckerman, J

Pan, Z

Wang, H

Shi, W

Robinson, RB

El-Maghrabi, MR

Benjamin, W

Dixon, J

McKinnon, D

Cohen, IS ^{[5
]}

Wymore, R

机构：

[1] Columbia Univ, Dept Pharmacol, New York, NY USA

[2] Univ Tulsa, Dept Biol, Tulsa, OK 74104 USA

[3] SUNY Stony Brook, Dept Neurobiol & Behav, Stony Brook, NY 11794 USA

[4] SUNY Stony Brook, Inst Mol Cardiol, Stony Brook, NY 11794 USA

[5] SUNY Stony Brook, Dept Physiol & Biophys, Stony Brook, NY 11794 USA

来源：

CIRCULATION RESEARCH | 2001年 / 88卷 / 12期

关键词：

HCN family; MiRP1; KCNE family; beta subunit;

D O I：

10.1161/hh1201.093511

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The HCN family of ion channel subunits underlies the currents I-f in heart and I-h and I-q in the nervous system. In the present study, we demonstrate that minK-related peptide 1 (MiRP1) is a beta subunit for the HCN family. As such, it enhances protein and current expression as well as accelerating the kinetics of activation. Because MiRP1 also functions as a beta subunit for the cardiac delayed rectifier I-Kr, these results suggest that this peptide may have the unique role of regulating both the inward and outward channels that underlie cardiac pacemaker activity. The full text of this article is available at http://www.circresaha.org.

引用

页码：E84 / E87

页数：4

共 11 条

[1] MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia [J].