Dietary Selenium for the counteraction of oxidative damage: fortified foods or supplements?

被引:25
作者
Bordoni, Alessandra [1 ]
Danesi, Francesca [1 ]
Malaguti, Marco [1 ]
Di Nunzio, Mattia [1 ]
Pasqui, Francesca [2 ]
Maranesi, Magda [1 ]
Biagi, Pier Luigi [1 ]
机构
[1] Univ Bologna, Dept Biochem G Moruzzi, Res Ctr Nutr & Vitaminol, I-40126 Bologna, Italy
[2] Univ Bologna, Policlin S Orsola, Dept Internal Med & Gastroenteroll, I-40138 Bologna, Italy
关键词
selenium; oxidative stress; selenium-enriched food; sodium selenite;
D O I
10.1017/S0007114507793911
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Since any significant modification in the Se status, leading to changes in the activity of the seleno-enzymes, may have important consequences on the susceptibility of tissues to oxidative stress, considerable efforts have been made upon increasing Se dietary intake. In this respect, an important debate is still open about the bioavailability and the effectiveness of Se, and more generally nutrients, in supplements compared with foods. Using male Wistar rats, we have compared the effectiveness of two different diets in which an adequate Se content (0.1 mg/kg) was achieved by adding the element as sodium selenite or as component of a lyophilized Se-enriched food, in the counteraction of an oxidative stress induced by intraperitoneal administration of adriamycin. Both Se-enriched diets were able to reduce the consequences of the oxidative stress in liver, mainly by increasing glutathione peroxidase activity. This increase was more evident in rats fed on the diet enriched with the lyophilized food, probably due to the different chemical forms of Se, or to other components of the food itself. Although further studies are needed, data herein presented may contribute to the characterization of the effectiveness of Se from different sources, foods or supplements, in the light of dietary advice to the population concerning improvement of Se intake.
引用
收藏
页码:191 / 197
页数:7
相关论文
共 43 条
[1]  
Aboul-Fadl Tarek, 2005, Current Medicinal Chemistry - Anti-Cancer Agents, V5, P637, DOI 10.2174/156801105774574676
[2]  
Akerboom T P, 1981, Methods Enzymol, V77, P373
[3]  
Arthur JR, 2000, CELL MOL LIFE SCI, V57, P1825
[4]   CHEMICAL FORMS OF SELENIUM IN RAT-TISSUES AFTER ADMINISTRATION OF SELENITE OR SELENOMETHIONINE [J].
BEILSTEIN, MA ;
WHANGER, PD .
JOURNAL OF NUTRITION, 1986, 116 (09) :1711-1719
[5]   Susceptibility to hypoxia/reoxygenation of aged rat cardiomyocytes and its modulation by selenium supplementation [J].
Bordoni, A ;
Biagi, PL ;
Angeloni, C ;
Leoncim, E ;
Danesi, F ;
Hrelia, S .
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2005, 53 (02) :490-494
[6]  
Bordoni A, 1996, MOL CELL BIOCHEM, V157, P217
[7]   Selenium supplementation can protect cultured rat cardiomyocytes from hypoxia/reoxygenation damage [J].
Bordoni, A ;
Biagi, PL ;
Angeloni, C ;
Leoncini, E ;
Muccinelli, I ;
Hrelia, S .
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2003, 51 (06) :1736-1740
[8]  
Brenneisen Peter, 2005, Molecular Aspects of Medicine, V26, P256, DOI 10.1016/j.mam.2005.07.004
[9]   MYOCARDIAL ALTERATIONS DUE TO FREE-RADICAL GENERATION [J].
BURTON, KP ;
MCCORD, JM ;
GHAI, G .
AMERICAN JOURNAL OF PHYSIOLOGY, 1984, 246 (06) :H776-H783
[10]  
Çelik S, 1999, CELL BIOCHEM FUNCT, V17, P115, DOI 10.1002/(SICI)1099-0844(199906)17:2&lt