ComPPARtmentalizing NF-κB in the gut

被引：17

作者：

Beg, AA ^{[1
]}

机构：

[1] Columbia Univ, Dept Biol Sci, New York, NY 10027 USA

来源：

NATURE IMMUNOLOGY | 2004年 / 5卷 / 01期

关键词：

D O I：

10.1038/ni0104-14

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

How do commensal gut bacteria coexist with the host without causing uncontrolled inflammation? The answer may lie in the induction of the association of PPAR-gamma with NF-kappaB.

引用

页码：14 / 16

页数：4

共 12 条

[1] PPAR-γ dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation [J].

Chawla, A ;

Barak, Y ;

Nagy, L ;

Liao, D ;

Tontonoz, P ;

Evans, RM .

NATURE MEDICINE, 2001, 7 (01) :48-52

[2] Molecular analysis of commensal host-microbial relations hips in the intestine [J].

Hooper, LV ;

Wong, MH ;

Thelin, A ;

Hansson, L ;

Falk, PC ;

Gordon, JI .

SCIENCE, 2001, 291 (5505) :881-884

[3] PPAR-γ agonists inhibit production of monocyte inflammatory cytokines [J].

Jiang, CY ;

Ting, AT ;

Seed, B .

NATURE, 1998, 391 (6662) :82-86

[4] Commensal anaerobic gut bacteria attenuate inflammation by regulating nuclear-cytoplasmic shuttling of PPAR-γ and RelA [J].

Kelly, D ;

Campbell, JI ;

King, TP ;

Grant, G ;

Jansson, EA ;

Coutts, AGP ;

Pettersson, S ;

Conway, S .

NATURE IMMUNOLOGY, 2004, 5 (01) :104-112

[5] PPARγ mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance [J].

Kubota, N ;

Terauchi, Y ;

Miki, H ;

Tamemoto, H ;

Yamauchi, T ;

Komeda, K ;

Satoh, S ;

Nakano, R ;

Ishii, C ;

Sugiyama, T ;

Eto, K ;

Tsubamoto, Y ;

Okuno, A ;

Murakami, K ;

Sekihara, H ;

Hasegawa, G ;

Naito, M ;

Toyoshima, Y ;

Tanaka, S ;

Shiota, K ;

Kitamura, T ;

Fujita, T ;

Ezaki, O ;

Aizawa, S ;

Nagai, R ;

Tobe, K ;

Kimura, S ;

Kadowaki, T .

MOLECULAR CELL, 1999, 4 (04) :597-609

[6] Prokaryotic regulation of epithelial responses by inhibition of IκB-α ubiquitination [J].

Neish, AS ;

Gewirtz, AT ;

Zeng, H ;

Young, AN ;

Hobert, ME ;

Karmali, V ;

Rao, AS ;

Madara, JL .

SCIENCE, 2000, 289 (5484) :1560-1563

[7] Inhibition of the mitogen-activated protein kinase kinase superfamily by a Yersinia effector [J].

Orth, K ;

Palmer, LE ;

Bao, ZQ ;

Stewart, S ;

Rudolph, AE ;

Bliska, JB ;

Dixon, JE .

SCIENCE, 1999, 285 (5435) :1920-1923

[8] The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation [J].

Ricote, M ;

Li, AC ;

Willson, TM ;

Kelly, CJ ;

Glass, CK .

NATURE, 1998, 391 (6662) :79-82

[9]

Setoguchi K, 2001, J CLIN INVEST, V108, P1667

[10] A novel therapy for colitis utilizing PPAR-γ ligands to inhibit the epithelial inflammatory response [J].

Su, CG ;

Wen, XM ;

Bailey, ST ;

Jiang, W ;

Rangwala, SM ;

Keilbaugh, SA ;

Flanigan, A ;

Murthy, S ;

Lazar, MA ;

Wu, GD .

JOURNAL OF CLINICAL INVESTIGATION, 1999, 104 (04) :383-389

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