Molecular recognition of RNA by neomycin and a restricted neomycin derivative

被引：78

作者：

Zhao, F

Zhao, Q

Blount, KF

Han, Q

Tor, Y

Hermann, T ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA

[2] Anadys Pharmaceut Inc, Dept Struct Chem, San Diego, CA 92121 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 33期

关键词：

antibiotics; glycosides; RNA recognition; RNA; X-ray crystallography;

D O I：

10.1002/anie.200500903

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) The preorganized presentation of functional groups in the antibiotic neomycin (green) is exploited to obtain a conformationally restricted aminoglycoside (yellow) by regioselective intramolecular cyclization. X-ray crystallography data show how the natural product and the derivative recognize the RNA target motif that is the binding site of aminoglycoside antibiotics. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

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收藏

页码：5329 / 5334

页数：6

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