Warfarin safety and efficacy in patients with thoracic aortic plaque and atrial fibrillation

被引：41

作者：

Blackshear, JL

Zabalgoitia, M

Pennock, G

Fenster, P

Strauss, R

Halperin, J

Asinger, R

Pearce, LA

机构：

[1] Mayo Clin Jacksonville, Div Cardiovasc Dis, Jacksonville, FL 32224 USA

[2] Univ Texas, Hlth Sci Ctr, San Antonio, TX USA

[3] Vet Affairs Med Ctr, Tucson, AZ USA

[4] Arizona Hlth Sci Ctr, Tucson, AZ 85724 USA

[5] Kaiser Sunnyside Med Ctr, Clackamas, OR USA

[6] Mt Sinai Med Ctr, New York, NY 10029 USA

[7] Hennepin Cty Med Ctr, Minneapolis, MN 55415 USA

[8] SPAF Stat Ctr, Seattle, WA USA

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 1999年 / 83卷 / 03期

关键词：

D O I：

10.1016/S0002-9149(98)00886-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Patients with atrial fibrillation and with documented aortic plaque who were assigned to adjusted-dose warfarin therapy (international normalized ratio 2.0 to 3.0) had an annual rate of cholesterol embolization of 0.7% (95% confidence interval [CI] 0.1% to 5.3%/patient-year). Warfarin-assigned patients with plaque had a lower rate of embolic events (5.9%/year; 95% CI 3.0 to 12) than those on combination low-dose warfarin (international normalized ratio <1.5) plus aspirin (17.3%/year; 95% CI 11 to 27; p = 0.01).

引用

页码：453 / +

页数：4

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