Crippling HIV one mutation at a time

被引：33

作者：

Allen, Todd M. ^{[1
]}

Altfeld, Marcus ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Partners AIDS Res Ctr, Boston, MA 02129 USA

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2008年 / 205卷 / 05期

关键词：

D O I：

10.1084/jem.20080569

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Accumulating data suggest that not all human immunodeficiency virus (HIV)-1 -specific immune responses are equally effective at controlling HIV-1 replication. A new study now demonstrates that multiple immune-driven sequence polymorphisms in the highly conserved HIV-1 Gag region of transmitted viruses are associated with reduced viral replication in newly infected humans. These data suggest that targeting these and other conserved viral regions may be the key to developing an effective HIV-1 vaccine.

引用

页码：1003 / 1007

页数：5

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