Historical Origins of Transdifferentiation and Reprogramming

被引：152

作者：

Graf, Thomas ^{[1
,2
]}

机构：

[1] Ctr Genom Regulat, Barcelona 08003, Spain

[2] Pompeu Fabra Univ, Barcelona 08003, Spain

来源：

CELL STEM CELL | 2011年 / 9卷 / 06期

关键词：

PLURIPOTENT STEM-CELLS; DEPENDENT DNA-POLYMERASE; CHICKEN ERYTHROID-CELLS; E26; LEUKEMIA-VIRUS; LINEAGE COMMITMENT; T-CELLS; B-CELLS; HEMATOPOIETIC-CELLS; DIRECT CONVERSION; MYELOID-LEUKEMIA;

D O I：

10.1016/j.stem.2011.11.012

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Transcription factor-induced reprogramming of specialized cells into other cell types and to pluripotency has revolutionized our thinking about cell plasticity, differentiation, and stem cells. The recent advances in this area were enabled by the confluence of a number of experimental breakthroughs that took place over the past 60 years. In this article, I give a historical and personal perspective of the events that set the stage for our current understanding of cellular reprogramming.

引用

页码：504 / 516

页数：13

共 132 条

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