First stereocontrolled syntheses of unsymmetrically substituted bislactone lignans: Stereocontrolled syntheses of four possible isomers of methyl 4,8-dioxoxanthoxylol

被引：35

作者：

Yoshida, S ^{[1
]}

Ogiku, T ^{[1
]}

Ohmizu, H ^{[1
]}

Iwasaki, T ^{[1
]}

机构：

[1] TANABE SEIYAKU CO LTD,LEAD OPTIMIZAT RES LAB,OSAKA 532,JAPAN

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1997年 / 62卷 / 05期

关键词：

D O I：

10.1021/jo961733y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient method for stereocontrolled syntheses of the unsymmetrically substituted bislactone subgroup of the furofuran lignan has been developed based on a stereoselective aldol reaction of the acid anhydride 8 or 9 and an aromatic aldehyde employing methyl 4,8-dioxoxanthoxylol (1a), 4,8-dioxofargesin (1b), methyl 4,8-dioxopiperitol (2a) and their isomer 3a as the representative examples of the axial-equatorial 1, diequatorial 2, and diaxial 3 types of this series.

引用

页码：1310 / 1316

页数：7

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