The bittersweet promise of glycobiology

被引:136
作者
Dove, A
机构
基金
美国国家卫生研究院;
关键词
Glycobiology;
D O I
10.1038/nbt1001-913
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Carbohydrates play a wide range of important roles in the body and, despite the challenges posed by glycobiology, are now tempting targets for drug developers.
引用
收藏
页码:913 / 917
页数:5
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共 4 条
  • [1] Structure, mechanism and engineering of a nucleotidylyltransferase as a first step toward glycorandomization
    Barton, WA
    Lesniak, J
    Biggins, JB
    Jeffrey, PD
    Jiang, JQ
    Rajashankar, KR
    Thorson, JS
    Nikolov, DB
    [J]. NATURE STRUCTURAL BIOLOGY, 2001, 8 (06) : 545 - 551
  • [2] Automated solid-phase synthesis of oligosaccharides
    Plante, OJ
    Palmacci, ER
    Seeberger, PH
    [J]. SCIENCE, 2001, 291 (5508) : 1523 - 1527
  • [3] Engineering Chinese hamster ovary cells to maximize sialic acid content of recombinant glycoproteins
    Weikert, S
    Papac, D
    Briggs, J
    Cowfer, D
    Tom, S
    Gawlitzek, M
    Lofgren, J
    Mehta, S
    Chisholm, V
    Modi, N
    Eppler, S
    Carroll, K
    Chamow, S
    Peers, D
    Berman, P
    Krummen, L
    [J]. NATURE BIOTECHNOLOGY, 1999, 17 (11) : 1116 - 1121
  • [4] Imino sugars inhibit the formation and secretion of bovine viral diarrhea virus, a pestivirus model of hepatitis C virus:: Implications for the development of broad spectrum anti-hepatitis virus agents
    Zitzmann, N
    Mehta, AS
    Carrouée, S
    Butters, TD
    Platt, FM
    McCauley, J
    Blumberg, BS
    Dwek, RA
    Block, TM
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (21) : 11878 - 11882