Mouse hepatitis virus

被引：62

作者：

Haring, J ^{[1
]}

Perlman, S ^{[1
]}

机构：

[1] Univ Iowa, Dept Microbiol, Med Labs 2042, Iowa City, IA 52242 USA

来源：

CURRENT OPINION IN MICROBIOLOGY | 2001年 / 4卷 / 04期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S1369-5274(00)00236-8

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Inoculation of mice with most neurotropic strains of the coronavirus mouse hepatitis virus results in an immune response-mediated demyelinating disease that serves as an excellent animal model for the human disease multiple sclerosis. Recent work has shown that either virus-specific CD4(+) or CD8(+) T cells are able to mediate demyelination and also that the antibody response is crucial for clearing infectious virus. Another exciting advance is the development of recombinant coronaviruses, which, for the first time, will allow genetic manipulation of the entire viral genome.

引用

页码：462 / 466

页数：5

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