Isopentenyl diphosphate is the terminal product of the deoxyxylulose-5-phosphate pathway for terpenoid biosynthesis in plants.

被引：36

作者：

McCaskill, D ^{[1
]}

Croteau, R ^{[1
]}

机构：

[1] Washington State Univ, Inst Biol Chem, Pullman, WA 99164 USA

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 04期

关键词：

terpenoid biosynthesis; isopentenyl diphosphate isomerase; deoxyxylulose-5-phosphate; isopentenyl diphosphate; dimethylallyl diphosphate; 2-(dimethylamino)ethyl diphosphate;

D O I：

10.1016/S0040-4039(98)02496-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Secretory cells specialized for monoterpene biosynthesis via the deoxyxylulose-5-phosphate pathway for terpenoid biosynthesis were isolated from peppermint (Mentha piperita) leaves and used to identify the terminal metabolite of this novel pathway. Incorporation of both [C-13]- and [C-14]pyruvic acid into monoterpenes in the presence of 2-(ditnethylamino)ethyl diphosphate, an inhibitor of isopentenyl diphosphate isomerase, results in accumulation of isopentenyl diphosphate, and not dimethylallyl diphosphate. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：653 / 656

页数：4

共 12 条

[1]

BURKE C, UNPUB

[2] Monoterpenoid essential oils are not of Mevalonoid origin [J].

Eisenreich, W ;

Sagner, S ;

Zenk, MH ;

Bacher, A .

TETRAHEDRON LETTERS, 1997, 38 (22) :3889-3892

[3] A family of transketolases that directs isoprenoid biosynthesis via a mevalonate-independent pathway [J].

Lange, BM ;

Wildung, MR ;

McCaskill, D ;

Croteau, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (05) :2100-2104

[4] Two independent biochemical pathways for isopentenyl diphosphate and isoprenoid biosynthesis in higher plants [J].

Lichtenthaler, HK ;

Rohmer, M ;

Schwender, J .

PHYSIOLOGIA PLANTARUM, 1997, 101 (03) :643-652

[5]

MCCASKILL D, 1992, PLANTA, V187, P445, DOI 10.1007/BF00199962

[6]

MCCASKILL D, 1995, PLANTA, V197, P49, DOI 10.1007/BF00239938

[7] PROCEDURES FOR THE ISOLATION AND QUANTIFICATION OF THE INTERMEDIATES OF THE MEVALONIC ACID PATHWAY [J].

MCCASKILL, D ;

CROTEAU, R .

ANALYTICAL BIOCHEMISTRY, 1993, 215 (01) :142-149

[8] Biochemistry by numbers: simulation of biochemical pathways with Gepasi 3 [J].

Mendes, P .

TRENDS IN BIOCHEMICAL SCIENCES, 1997, 22 (09) :361-363

[9] ISOPENTENYL-DIPHOSPHATE ISOMERASE - INACTIVATION OF THE ENZYME WITH ACTIVE-SITE-DIRECTED IRREVERSIBLE INHIBITORS AND TRANSITION-STATE ANALOGS [J].

MUEHLBACHER, M ;

POULTER, CD .

BIOCHEMISTRY, 1988, 27 (19) :7315-7328

[10] CHARACTERIZATION AND MECHANISM OF (4S)-LIMONENE SYNTHASE, A MONOTERPENE CYCLASE FROM THE GLANDULAR TRICHOMES OF PEPPERMINT (MENTHA X PIPERITA) [J].

RAJAONARIVONY, JIM ;

GERSHENZON, J ;

CROTEAU, R .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1992, 296 (01) :49-57

← 1 2 →